Open AccessThree Novel <b><i>MEN1</i></b> Variants in <b><i>AIP</i></b>-Negative Familial Isolated Pituitary Adenoma Patients
Author(s) -
Sema Yarman,
Feyza Nur Tuncer,
Esin Serbest
Publication year - 2019
Publication title -
pathobiology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 53
eISSN - 1423-0291
pISSN - 1015-2008
DOI - 10.1159/000495252
Subject(s) - men1 , mutation , medicine , microbiology and biotechnology , endocrinology , biology , multiple endocrine neoplasia , genetics , gene
Pituitary adenomas (PAs) may rarely occur in well-defined hereditary conditions, like multiple endocrine neoplasia type 1 (MEN1) syndrome and familial isolated pituitary adenoma (FIPA) associated with germline mutations in MEN1 and AIP, respectively. This study aimed to assess MEN1 genetic abnormalities in AIP mutation-negative FIPA patients, not associated with MEN1 components.