Open AccessNo Evidence of Microsatellite Instability and Loss of Mismatch-Repair-Protein Expression in Squamous Cell Carcinoma of the Penis
Author(s) -
Robert Stoehr,
Olaf Wendler,
Johannes Giedl,
Nadine T. Gaisa,
G. Richter,
Valentina Câmpean,
Maximilian Burger,
Bernd Wullich,
Simone Bertz,
Arndt Hartmann
Publication year - 2019
Publication title -
pathobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 53
eISSN - 1423-0291
pISSN - 1015-2008
DOI - 10.1159/000495251
Subject(s) - msh2 , microsatellite instability , msh6 , mlh1 , pms2 , tissue microarray , dna mismatch repair , penile cancer , immunohistochemistry , cancer research , medicine , cancer , pathology , oncology , biology , genetics , microsatellite , allele , colorectal cancer , gene
Microsatellite instability (MSI) and a defective mismatch repair (MMR) system were described as beneficial tumor features for response to immune checkpoint therapy (PD-1 blockade). Meanwhile, the FDA approved PD-1/PD-L1 inhibition treatment for any solid tumor showing MSI and/or defects in the MMR system. For squamous cell carcinoma (SCC) of the penis, no data on the frequency of MSI and altered MMR protein expression are available to date. Therefore, we investigated the MSI status and the expression of MMR proteins in a large cohort of penile SCCs.