Open AccessSkeletal Morbidity in Children and Adolescents during and following Cancer Therapy
Author(s) -
Sogol MostoufiMoab,
Leanne M. Ward
Publication year - 2018
Publication title -
hormone research in paediatrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.816
H-Index - 89
eISSN - 1663-2826
pISSN - 1663-2818
DOI - 10.1159/000494809
Subject(s) - medicine , childhood cancer , malignancy , quality of life (healthcare) , cancer therapy , pediatrics , cancer , skeleton (computer programming) , intensive care medicine , physical therapy , nursing , anatomy
Skeletal abnormalities are common in children and adolescents diagnosed and treated for a malignancy. The spectrum ranges from mild pain to debilitating osteonecrosis and fractures. In this review, we summarize the impact of cancer therapy on the developing skeleton, provide an update on therapeutic strategies for prevention and treatment, and discuss the most recent advances in musculoskeletal research. Early recognition of skeletal abnormalities and strategies to optimize bone health are essential to prevent long-term skeletal sequelae and diminished quality of life in childhood cancer survivors.