Open AccessDandy-Walker Malformation-Like Condition Revealed by Refractory Schizophrenia: A Case Report and Literature Review
Author(s) -
Maxime Tréhout,
Norbert Zhang,
Marie Blouet,
Alin Borha,
Sonia Dollfus
Publication year - 2018
Publication title -
neuropsychobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.71
H-Index - 83
eISSN - 1423-0224
pISSN - 0302-282X
DOI - 10.1159/000494695
Subject(s) - schizophrenia (object oriented programming) , pediatrics , dandy–walker syndrome , fourth ventricle , psychosis , agenesis , psychology , medicine , psychiatry , hydrocephalus , surgery
Dandy-Walker malformation is a rare congenital malformation involving cystic dilatation of the fourth ventricle, enlarged posterior fossa, complete or partial agenesis of the cerebellar vermis, elevated tentorium cerebelli, and hydrocephalus. Previous research highlighted a possible role for the cerebellum in schizophrenia as well as the contribution of underlying brain malformations to treatment resistance. Here, we present a case of a Dandy-Walker malformation-like condition revealed by a refractory schizophrenia in a 24-year-old male patient. We also conduct a literature review of all previously published case reports or case series of co-occurring posterior fossa abnormalities and schizophrenia or psychosis using a PubMed search query to better understand the potential link between these two disorders.