Open AccessCXCR4 Accelerates Osteoclastogenesis Induced by Non-Small Cell Lung Carcinoma Cells Through Self-Potentiation and VCAM1 Secretion
Author(s) -
Tongquan Liao,
Wugui Chen,
Jing Sun,
Ying Zhang,
Xu Hu,
Sizhen Yang,
Hao Qiu,
Songtao Li,
Tongwei Chu
Publication year - 2018
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000494533
Subject(s) - metastasis , osteoclast , cxcr4 , cancer research , lung cancer , bone metastasis , medicine , biology , pathology , chemistry , cancer , chemokine , inflammation , receptor
Non-small cell lung carcinoma (NSCLC) metastasis to bone leads to skeletal-related events and a poor quality of life. Unravelling the mechanism of metastasis is crucial for improving survival. Previous work has implicated the role of CXCR4 in bone metastasis; however, the underlying mechanisms are unknown.