CXCR4 Accelerates Osteoclastogenesis Induced by Non-Small Cell Lung Carcinoma Cells Through Self-Potentiation and VCAM1 Secretion | Zendy

Tongquan Liao | Zendy; Wugui Chen | Zendy; Jing Sun | Zendy; Ying Zhang | Zendy; Xu Hu | Zendy; Sizhen Yang | Zendy; Hao Qiu | Zendy; Songtao Li | Zendy; Tongwei Chu | Zendy

Open Access

CXCR4 Accelerates Osteoclastogenesis Induced by Non-Small Cell Lung Carcinoma Cells Through Self-Potentiation and VCAM1 Secretion

Author(s) -

Tongquan Liao,

Wugui Chen,

Jing Sun,

Ying Zhang,

Xu Hu,

Sizhen Yang,

Hao Qiu,

Songtao Li,

Tongwei Chu

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000494533

Subject(s) - metastasis , osteoclast , cxcr4 , cancer research , lung cancer , bone metastasis , medicine , biology , pathology , chemistry , cancer , chemokine , inflammation , receptor

Non-small cell lung carcinoma (NSCLC) metastasis to bone leads to skeletal-related events and a poor quality of life. Unravelling the mechanism of metastasis is crucial for improving survival. Previous work has implicated the role of CXCR4 in bone metastasis; however, the underlying mechanisms are unknown.

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