Open AccessThe Impact of the Opioid Antagonist Naloxone on Experimentally Induced Craving in Nicotine-Dependent Individuals
Author(s) -
Daniela Krause,
Marc Warnecke,
Christian Schuetz,
Michael Soyka,
Kirsi Manz,
Lisa Proebstl,
Felicia Kamp,
Agnieszka Chrobok,
Oliver Pogarell,
Gabriele Koller
Publication year - 2018
Publication title -
european addiction research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.862
H-Index - 54
eISSN - 1421-9891
pISSN - 1022-6877
DOI - 10.1159/000494346
Subject(s) - nicotine , craving , (+) naloxone , placebo , psychology , antagonist , prolactin , opioid , endogenous opioid , medicine , narcotic antagonist , anesthesia , dipper , opioid antagonist , endocrinology , pharmacology , addiction , psychiatry , receptor , hormone , blood pressure , ambulatory blood pressure , alternative medicine , pathology
Preclinical and clinical findings suggest a substantial association of the endogenous opioid system in nicotine dependence. The present study investigates the possible dose-dependent influence of naloxone, an unspecific opioid-receptor-antagonist, combined with cue exposure on the physiological state, locomotor activity, craving and the hypothalamic-pituitary-adrenal axis in nicotine-dependent humans.