The Impact of the Opioid Antagonist Naloxone on Experimentally Induced Craving in Nicotine-Dependent Individuals | Zendy

Daniela Krause | Zendy; Marc Warnecke | Zendy; Christian Schuetz | Zendy; Michael B. Soyka | Zendy; Kirsi Manz | Zendy; Lisa Proebstl | Zendy; Felicia Kamp | Zendy; Agnieszka I. Chrobok | Zendy; Oliver Pogarell | Zendy; Gabriele Koller | Zendy

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The Impact of the Opioid Antagonist Naloxone on Experimentally Induced Craving in Nicotine-Dependent Individuals

Author(s) -

Daniela Krause,

Marc Warnecke,

Christian Schuetz,

Michael B. Soyka,

Kirsi Manz,

Lisa Proebstl,

Felicia Kamp,

Agnieszka I. Chrobok,

Oliver Pogarell,

Gabriele Koller

Publication year - 2018

Publication title -

european addiction research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.862

H-Index - 54

eISSN - 1421-9891

pISSN - 1022-6877

DOI - 10.1159/000494346

Subject(s) - nicotine , craving , (+) naloxone , placebo , psychology , antagonist , prolactin , opioid , endogenous opioid , medicine , narcotic antagonist , anesthesia , dipper , opioid antagonist , endocrinology , pharmacology , addiction , psychiatry , receptor , hormone , blood pressure , ambulatory blood pressure , alternative medicine , pathology

Preclinical and clinical findings suggest a substantial association of the endogenous opioid system in nicotine dependence. The present study investigates the possible dose-dependent influence of naloxone, an unspecific opioid-receptor-antagonist, combined with cue exposure on the physiological state, locomotor activity, craving and the hypothalamic-pituitary-adrenal axis in nicotine-dependent humans.

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