Open AccessVariants in <b><i>APOA5</i></b> and <b><i>ADIPOQ</i></b> Moderate Improvements in Metabolic Syndrome during a One-Year Lifestyle Intervention
Author(s) -
Dana E Lowry,
Peri H Fenwick,
Kaitlin Roke,
Khursheed N. Jeejeebhoy,
Rupinder Dhaliwal,
Paula Brauer,
Dawna Royall,
Angelo Tremblay,
Doug Klein,
David M. Mutch
Publication year - 2018
Publication title -
lifestyle genomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 30
eISSN - 2504-3188
pISSN - 2504-3161
DOI - 10.1159/000494331
Subject(s) - single nucleotide polymorphism , adiponectin , medicine , minor allele frequency , metabolic syndrome , dyslipidemia , cohort , obesity , genetics , biology , insulin resistance , genotype , gene
Metabolic syndrome (MetS) comprises a cluster of risk factors including central obesity, hypertension, dyslipidemia, and impaired glucose homeostasis. Lifestyle interventions that promote improvements in diet quality and physical activity represent a first line of therapy for MetS. However, varying responses to lifestyle interventions are well documented and may be partially explained by underlying genetic differences. The aim of this study was to investigate if variants in genes previously associated with MetS influence the magnitude of change in MetS risk during a 1-year lifestyle intervention.