Human Endogenous Retroviruses: Residues of Ancient Times Are Differentially Expressed in Crohn’s Disease | Zendy

Thomas Klag | Zendy; Lioba Courth | Zendy; Maureen J. Ostaff | Zendy; German Ott | Zendy; Eduard F. Stange | Zendy; Nisar P. Malek | Zendy; Wolfgang Seifarth | Zendy; Jan Wehkamp | Zendy

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Human Endogenous Retroviruses: Residues of Ancient Times Are Differentially Expressed in Crohn’s Disease

Author(s) -

Thomas Klag,

Lioba Courth,

Maureen J. Ostaff,

German Ott,

Eduard F. Stange,

Nisar P. Malek,

Wolfgang Seifarth,

Jan Wehkamp

Publication year - 2018

Publication title -

inflammatory intestinal diseases

Language(s) - English

Resource type - Journals

eISSN - 2296-9403

pISSN - 2296-9365

DOI - 10.1159/000494026

Subject(s) - endogenous retrovirus , crohn's disease , endogeny , virology , disease , biology , genetics , medicine , gene , genome , biochemistry , pathology

Eight percent of the human genome consists of human endogenous retroviruses (HERV). These genetic elements are remnants of ancient retroviral germ-line infections. Altered HERV expression is associated with several chronic inflammatory diseases. A physiological role of the HERV-derived proteins syncytin-1 and -2 has been described for the integrity of the human placental cell layer in terms of maintaining feto-maternal tolerance. The aim of this project was to investigate HERV expression in Crohn's disease (CD) with a further focus on syncytins in the gut.

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