Open AccessBrain Gene Expression Pattern of Subjects with Completed Suicide and Comorbid Substance Use Disorder
Author(s) -
Brenda Cabrera,
Nancy Monroy-Jaramillo,
Gabriel R. Fries,
Roberto Cuauhtemoc Mendoza-Morales,
Fernando García-Dolores,
A Mendoza-Larios,
Carlos Enrique Díaz-Otañez,
Consuelo WalssBass,
David C. Glahn,
Patricia OstroskyWegman,
Cristóbal Fresno,
Humberto Nicolini
Publication year - 2018
Publication title -
complex psychiatry
Language(s) - English
Resource type - Journals
eISSN - 2673-3005
pISSN - 2673-298X
DOI - 10.1159/000493940
Subject(s) - substance use , psychology , psychiatry , substance abuse , expression (computer science) , comorbidity , clinical psychology , medicine , neuroscience , computer science , programming language
Although individuals with substance use disorder (SUD) are at high risk of committing suicide, most studies of postmortem gene expression exclude subjects with SUD due to the potential confounding effect of drugs in the transcriptome. Thus, little is known about the gene expression profile in suicides with SUD. The identification of altered biological processes in suicides with SUD is crucial in the comprehension of the interaction between both pathologies.