The Detergent Effect of Mesalazine Interferes with Phosphatidylcholine Binding to Mucin 2 | Zendy

Wolfgang Stremmel | Zendy; Simone Staffer | Zendy; Sven G. Gehrke | Zendy

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The Detergent Effect of Mesalazine Interferes with Phosphatidylcholine Binding to Mucin 2

Author(s) -

Wolfgang Stremmel,

Simone Staffer,

Sven G. Gehrke

Publication year - 2018

Publication title -

inflammatory intestinal diseases

Language(s) - English

Resource type - Journals

eISSN - 2296-9403

pISSN - 2296-9365

DOI - 10.1159/000493347

Subject(s) - mesalazine , mucin , mucus , phosphatidylcholine , chemistry , colitis , pharmacology , medicine , ulcerative colitis , immunology , biochemistry , biology , phospholipid , membrane , ecology , disease

Therapeutically applied delayed-release phosphatidylcholine (PC) revealed mucosa protection and clinical improvement of ulcerative colitis. However, a recent trial with simultaneous application of delayed-release PC and mesalazine showed lack of efficacy. It is hypothesized that mesalazine acts as detergent to prohibit PC integration into mucus as target compartment, thus preventing topical mucus protection.

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