Open AccessThe Detergent Effect of Mesalazine Interferes with Phosphatidylcholine Binding to Mucin 2
Author(s) -
Wolfgang Stremmel,
Simone Staffer,
Sven G. Gehrke
Publication year - 2018
Publication title -
inflammatory intestinal diseases
Language(s) - English
Resource type - Journals
eISSN - 2296-9403
pISSN - 2296-9365
DOI - 10.1159/000493347
Subject(s) - mesalazine , mucin , mucus , phosphatidylcholine , chemistry , colitis , pharmacology , medicine , ulcerative colitis , immunology , biochemistry , biology , phospholipid , membrane , ecology , disease
Therapeutically applied delayed-release phosphatidylcholine (PC) revealed mucosa protection and clinical improvement of ulcerative colitis. However, a recent trial with simultaneous application of delayed-release PC and mesalazine showed lack of efficacy. It is hypothesized that mesalazine acts as detergent to prohibit PC integration into mucus as target compartment, thus preventing topical mucus protection.