Open AccessExosomes from Thymic Stromal Lymphopoietin-Activated Dendritic Cells Promote Th2 Differentiation through the OX40 Ligand
Author(s) -
Li Huang,
Xinxing Zhang,
Meijuan Wang,
Zhengrong Chen,
Yan Ya,
Wenjing Gu,
Jiahong Tan,
Wujun Jiang,
Wei Ji
Publication year - 2018
Publication title -
pathobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 53
eISSN - 1423-0291
pISSN - 1015-2008
DOI - 10.1159/000493013
Subject(s) - thymic stromal lymphopoietin , microvesicles , exosome , immunology , allergic inflammation , cytokine , stromal cell , flow cytometry , interleukin 4 , immune system , biology , chemistry , inflammation , cancer research , microrna , biochemistry , gene
Exosomes are extracellular vesicles released from various inflammatory cells, such as T cells, B cells, dendritic cells (DCs), and mast cells, which have been implicated in the modulation of immune response in asthma. This study aimed to investigate whether exosomes from DCs activated by thymic stromal lymphopoietin (TSLP) play a role in T-helper cell differentiation through the OX40 ligand (OX40L).