Open AccessNeonatal Alloimmune Neutropenia
Author(s) -
Leendert Porcelijn,
Masja de Haas
Publication year - 2018
Publication title -
transfusion medicine and hemotherapy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.971
H-Index - 39
eISSN - 1660-3818
pISSN - 1660-3796
DOI - 10.1159/000492949
Subject(s) - medicine , neutropenia , meningitis , neonatal alloimmune thrombocytopenia , pneumonia , immunology , sepsis , antibiotics , neonatal sepsis , incidence (geometry) , neonatal infection , fetus , leukopenia , pregnancy , pediatrics , biology , chemotherapy , microbiology and biotechnology , physics , optics , genetics
Neonatal alloimmune neutropenia (NAIN, NAIN or NIN) is a neutrophil blood group antagonism, analogous to hemolytic disease of the fetus and newborn (HDFN) and fetal/neonatal alloimmune thrombocytopenia (FNAIT). A limited number of prospective screening studies showed that granulocyte-specific antibodies were detectable in 0.35-1.1% of random postnatal maternal samples and that the incidence of NAIN was below 0.1%. Symptoms vary from none to mild skin infections, omphalitis or more severe infections like pneumonia, sepsis, and meningitis. Treatment of neonatal infection with antibiotics and granulocyte-colony stimulating factor is advised.