Open AccessProgression Potential of Ductal Carcinoma in situ Assessed by Genomic Copy Number Profiling
Author(s) -
Mina Kitamura,
Tadanobu Nakayama,
Kenichi Mukaisho,
Taisuke Mori,
Tomoko Umeda,
Suzuko Moritani,
Ryoji Kushima,
Masaji Tani,
Hiroyuki Sugihara
Publication year - 2018
Publication title -
pathobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 53
eISSN - 1423-0291
pISSN - 1015-2008
DOI - 10.1159/000492833
Subject(s) - ductal carcinoma , breast cancer , comparative genomic hybridization , immunohistochemistry , in situ hybridization , gata3 , cancer research , biology , medicine , pathology , cancer , gene , chromosome , gene expression , genetics , transcription factor
Ductal carcinoma in situ (DCIS) of the breast is heterogeneous in terms of the risk of progression to invasive ductal carcinoma (IDC). To treat DCIS appropriately for its progression risk, we classified individual DCIS by its profile of genomic changes into 2 groups and correlated them with clinicopathological progression factors.