Open AccessClinical Utility of Extracorporeal Cytokine Hemoadsorption Therapy: A Literature Review
Author(s) -
Anthony Bonavia,
Andrew Groff,
Kunal Karamchandani,
Kai Singbartl
Publication year - 2018
Publication title -
blood purification
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 57
eISSN - 1421-9735
pISSN - 0253-5068
DOI - 10.1159/000492379
Subject(s) - medicine , cytokine storm , sepsis , proinflammatory cytokine , septic shock , cytokine , context (archaeology) , intensive care medicine , immunology , immune system , disease , inflammation , infectious disease (medical specialty) , covid-19 , paleontology , biology
Cytokines play a critical role in coordinating and amplifying a host immune response to infection. The normal pattern of localized and systemic release of proinflammatory and anti-inflammatory cytokines varies on the basis of the disease process. A dysregulated cytokine response can lead to a hyper-inflammatory condition called a cytokine storm. This is believed to contribute to the pathophysiology of sepsis and septic shock, a condition carrying high morbidity and mortality in critically ill patients. Extracorporeal cytokine hemoadsorption is an emerging technology utilized in the treatment of dysregulated inflammatory states such as sepsis, although there is a paucity of clinical evidence supporting its outcomes benefits. We assess the peer-reviewed literature relating to cytokine hemoadsorption in the context of sepsis and suggest areas of future research incorporating this novel technology.