Open AccessAntioxidant Properties of Ferulic Acid and Its Possible Application
Author(s) -
Kamila Zduńska,
Agnieszka Dana,
Anna Kołodziejczak,
Helena Rotsztejn
Publication year - 2018
Publication title -
skin pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.703
H-Index - 74
eISSN - 1660-5535
pISSN - 1660-5527
DOI - 10.1159/000491755
Subject(s) - ferulic acid , chemistry , photoaging , antioxidant , scavenger , free radical scavenger , biochemistry , pharmacology , elastin , tyrosinase , enzyme , biology , medicine , dermatology , genetics
Ferulic acid has low toxicity and possesses many physiological functions (anti-inflammatory, antioxidant, antimicrobial activity, anticancer, and antidiabetic effect). It has been widely used in the pharmaceutical, food, and cosmetics industry. Ferulic acid is a free radical scavenger, but also an inhibitor of enzymes that catalyze free radical generation and an enhancer of scavenger enzyme activity. Ferulic acid has a protective role for the main skin structures: keratinocytes, fibroblasts, collagen, elastin. It inhibits melanogenesis, enhances angiogenesis, and accelerates wound healing. It is widely applied in skin care formulations as a photoprotective agent, delayer of skin photoaging processes, and brightening component. Nonetheless, its use is limited by its tendency to be rapidly oxidized.