Relationship between Ribosomal Protein S6-pS240 Expression and other Prognostic Factors in Non-Special Type Invasive Breast Cancer | Zendy

Frederik Çuperjani | Zendy; Lumturije Gashi | Zendy; Fisnik Kurshumliu | Zendy; Shemsedin Dreshaj | Zendy; Fitim Selimi | Zendy

Open Access

Relationship between Ribosomal Protein S6-pS240 Expression and other Prognostic Factors in Non-Special Type Invasive Breast Cancer

Author(s) -

Frederik Çuperjani,

Lumturije Gashi,

Fisnik Kurshumliu,

Shemsedin Dreshaj,

Fitim Selimi

Publication year - 2018

Publication title -

breast care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.767

H-Index - 30

eISSN - 1661-3805

pISSN - 1661-3791

DOI - 10.1159/000491427

Subject(s) - medicine , immunohistochemistry , nottingham prognostic index , breast cancer , ribosomal protein s6 , stage (stratigraphy) , lymphovascular invasion , oncology , estrogen receptor , proliferation index , ki 67 , lymph node , cancer , gynecology , pathology , biology , metastasis , apoptosis , paleontology , biochemistry , pi3k/akt/mtor pathway , p70 s6 kinase 1

Background: The aim of this study was to investigate the immunohistochemical expression of ribosomal protein (RP) S6-pS240 in non-special type invasive breast cancer in relation to other prognostic markers and gain new insights to facilitate more individualized treatment. Methods: The following clinical and histopathological parameters of 120 patients were determined: S6-pS240 expression, age, menopausal status, tumor size and grade, TNM stage, Nottingham Prognostic Index (NPI), lymph node stage, estrogen and progesterone receptor (ER/PR) expression, HER2/neu amplification, lymphovascular invasion, and proliferative index as measured by Ki-67. Treatment protocol and disease-free survival were evaluated accordingly. Results: Significant positive correlations were seen between S6-pS240 expression and Ki-67 values (rho = 0.530, p < 0.001), and NPI (rho = 0.370, p < 0.001) and HER2/neu amplification (rho = 0.368, p < 0.001). A negative correlation was found between S6-pS240 and ER/PR expression (rho = 0.362, p < 0.001). Patients with negative RP S6-pS240 expression had significantly longer disease-free survival (log-rank test, p = 0.005). Conclusion: Immunohistochemical analysis of RP S6-pS240 is a valuable additional prognostic marker in patients with invasive breast cancer. Routine use of S6-pS240 immunohistochemistry is recommended.

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