Open AccessManagement of Infectious Complications Associated with Acute-on-Chronic Liver Failure
Author(s) -
Cornelius Engelmann,
Thomas Berg
Publication year - 2018
Publication title -
visceral medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.598
H-Index - 17
eISSN - 2297-475X
pISSN - 2297-4725
DOI - 10.1159/000491107
Subject(s) - medicine , intensive care medicine , liver failure , surgery
Acute-on-chronic liver failure (ACLF) is associated with a high susceptibility to infections leading to complications and poor prognosis. The sensitized immune system overwhelmingly responds to invading bacteria leading to organ damage. After resolution of infection or prolonged disease duration, the phagocytic system becomes irresponsive with a reduced bacterial clearance capacity promoting secondary infection.