Open AccessAcute Hemolytic Transfusion Reaction due to Anti-P1: A Case Report and Review of Institutional Experience
Author(s) -
Debra L Smith,
Thandar Aye,
Lay See Er,
Theresa Nester,
Meghan Delaney
Publication year - 2018
Publication title -
transfusion medicine and hemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.971
H-Index - 39
eISSN - 1660-3818
pISSN - 1660-3796
DOI - 10.1159/000490897
Subject(s) - medicine , antibody , population , blood transfusion , pediatrics , immunology , environmental health
Here we report a case of acute hemolytic transfusion reaction (HTR) due to anti-P1 and review our institutional database for prevalence of anti-P1 antibodies and frequency of anti-P1-mediated HTR. Anti-P1 antibodies, reported to be present in up to two-thirds of P 2 individuals, are usually clinically insignificant. However, rare cases of acute HTR due to anti-P1 are reported. Case Report: We report the clinical and laboratory features of a mild acute HTR due to an IgM anti-P1 not detected by a routinely used antibody screening method. We reviewed our institutional database to investigate prevalence of anti-P1 antibodies identified in our patient population and frequency of HTR in patients with anti-P1.