Open AccessStudy of Deiodinase Type 2 Polymorphisms in Graves’ Disease and Ophthalmopathy in a Swedish Population
Author(s) -
Bushra Shahida,
Tereza Planck,
Peter Åsman,
Mikael Lantz
Publication year - 2018
Publication title -
european thyroid journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.23
H-Index - 10
eISSN - 2235-0802
pISSN - 2235-0640
DOI - 10.1159/000490892
Subject(s) - dio2 , deiodinase , medicine , trab , single nucleotide polymorphism , endocrinology , graves' disease , thyroid peroxidase , thyroid , triiodothyronine , genotype , biology , genetics , gene
Deiodinase type 2 (DIO2) is an enzyme that catalyzes the production of the active form of thyroid -hormone triiodothyronine (T3) from thyroxine (T4) and is important for maintaining intracellular T3 levels. Single nucleotide polymorphisms (SNPs) in DIO2 were associated with several diseases. The association of SNPs in DIO2 with Graves' disease (GD) was suggested in 2 Russian studies.