Open AccessFarnesoid X Receptor (FXR) Interacts with Camp Response Element Binding Protein (CREB) to Modulate Glucagon-Like Peptide-1 (7–36) Amide (GLP-1) Secretion by Intestinal L Cell
Author(s) -
Pengzhou Li,
Liyong Zhu,
Xiangwu Yang,
Weizheng Li,
Xulong Sun,
Bo Yi,
Shaihong Zhu
Publication year - 2018
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000490836
Subject(s) - creb , farnesoid x receptor , enteroendocrine cell , endocrinology , medicine , g protein coupled bile acid receptor , secretion , kegg , glucagon like peptide 1 , proglucagon , signal transduction , microbiology and biotechnology , biology , chemistry , transcription factor , nuclear receptor , hormone , gene expression , biochemistry , transcriptome , diabetes mellitus , endocrine system , type 2 diabetes , bile acid , gene
Type II diabetes is a complex, chronic, and progressive disease. Glucagon-like peptide-1 (7-6) amide (GLP-1) is a gut hormone released from the L cells which stimulates insulin secretion, and promotes insulin gene expression and β-cell growth and differentiation. Elevated levels of hormone secreted by L cells are an important reason for diabetes improvement. GLP-1 secretion has been reported to be regulated by farnesoid X receptor (FXR), a transcriptional sensor for bile acids which also acts on glucose metabolism. Herein, we attempted to evaluate the effect of FXR on GLP-1 secretion in mouse enteroendocrine L cell lines, STC-1 and GLUTag, and to investigate the underlying mechanism.