The Derived Neutrophil-to-Lymphocyte Ratio Is an Independent Prognostic Factor in Transplantation Ineligible Patients with Multiple Myeloma | Zendy

Gyeong Won Lee | Zendy; Sung Woo Park | Zendy; Se Il Go | Zendy; Hoon Gu Kim | Zendy; Min Kyoung Kim | Zendy; Chang Ki Min | Zendy; Jae Yong Kwak | Zendy; Sang Byung Bae | Zendy; Sung Soo Yoon | Zendy; Je Jung Lee | Zendy; Ki Hwan Kim | Zendy; Seung Hyun Nam | Zendy; Yeung Chul Mun | Zendy; Hyo Jung Kim | Zendy; Sung Hwa Bae | Zendy; Ho Jin Shin | Zendy; Jun Young Lee | Zendy; Joon Seong Park | Zendy; Seong Hyun Jeong | Zendy; Mark Hong Lee | Zendy; Ho Sup Lee | Zendy; Keon Woo Park | Zendy; Won Sik Lee | Zendy; Sang Min Lee | Zendy; Jeong-Ok Lee | Zendy; Myung Soo Hyun | Zendy; Deog Yeon Jo | Zendy; Sung Cil Lim | Zendy; Jae Hoon Lee | Zendy; Hawk Kim | Zendy; Do Yeun Cho | Zendy; Young Rok | Zendy; JeongA Kim | Zendy; Seong Kyu Park | Zendy; Jin Seok Kim | Zendy; Soo Jeong Kim | Zendy; Hyeon Gyu Yi | Zendy; Joon Ho Moon | Zendy; Chul Won Choi | Zendy; Sung Hyun Kim | Zendy; Byung Soo Kim | Zendy; Moo Rim Park | Zendy; Hyeok Shim | Zendy; Moo-Kon Song | Zendy; Youngdoe Kim | Zendy; Kihyun Kım | Zendy

Open Access

The Derived Neutrophil-to-Lymphocyte Ratio Is an Independent Prognostic Factor in Transplantation Ineligible Patients with Multiple Myeloma

Author(s) -

Gyeong Won Lee,

Sung Woo Park,

Se Il Go,

Hoon Gu Kim,

Min Kyoung Kim,

Chang Ki Min,

Jae Yong Kwak,

Sang Byung Bae,

Sung Soo Yoon,

Je Jung Lee,

Ki Hwan Kim,

Seung Hyun Nam,

Yeung Chul Mun,

Hyo Jung Kim,

Sung Hwa Bae,

Ho Jin Shin,

Jun Young Lee,

Joon Seong Park,

Seong Hyun Jeong,

Mark Hong Lee,

Ho Sup Lee,

Keon Woo Park,

Won Sik Lee,

Sang Min Lee,

Jeong-Ok Lee,

Myung Soo Hyun,

Deog Yeon Jo,

Sung Cil Lim,

Jae Hoon Lee,

Hawk Kim,

Do Yeun Cho,

Young Rok,

JeongA Kim,

Seong Kyu Park,

Jin Seok Kim,

Soo Jeong Kim,

Hyeon Gyu Yi,

Joon Ho Moon,

Chul Won Choi,

Sung Hyun Kim,

Byung Soo Kim,

Moo Rim Park,

Hyeok Shim,

Moo-Kon Song,

Youngdoe Kim,

Kihyun Kım

Publication year - 2018

Publication title -

acta haematologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.574

H-Index - 56

eISSN - 1421-9662

pISSN - 0001-5792

DOI - 10.1159/000490488

Subject(s) - multiple myeloma , gastroenterology , medicine , bortezomib , hazard ratio , melphalan , lymphocyte , urology , confidence interval

Background: The neutrophil-to-lymphocyte ratio (NLR) is an independent prognostic marker in solid and hematological cancers. While the derived NLR (dNLR) was shown to be non-inferior to the NLR in large cohorts of patients with different cancer types, it has not been validated as a prognostic marker for multiple myeloma (MM) to date. Methods: Between May 22, 2011 and May 29, 2014, 176 patients with MM from 38 centers who were ineligible for autologous stem cell transplantation were analyzed. The dNLR was calculated using complete blood count differential data. The optimal dNLR cut-off value according to receiver operating characteristic analysis of overall survival (OS) was 1.51. All patients were treated with melphalan and prednisone combined with bortezomib. Results: The complete response rate was lower in the high dNLR group compared to the low dNLR group (7 vs. 26.1%, respectively; p = 0.0148); the corresponding 2-year OS rates were 72.2 and 84.7%, respectively (p = 0.0354). A high dNLR was an independent poor prognostic factor for OS (hazard ratio 2.217, 95% CI 1.015–4.842; p = 0.0458). Conclusion: The dNLR is a readily available and cheaply obtained parameter in clinical studies, and shows considerable potential as a new prognostic marker for transplantation-ineligible patients with MM.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research