Open AccessRaddeanin a Suppresses Glioblastoma Growth by Inducing ROS Generation and Subsequent JNK Activation to Promote Cell Apoptosis
Author(s) -
Fei Peng,
X Wang,
S Mao,
Meimei Yang,
L Wang,
Zizhang Ouyang,
Chen Shen,
Xiaohong Hou,
Baolei Zhao,
L-W Zhang,
Liu Y,
Shen Zhao
Publication year - 2018
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000490187
Subject(s) - apoptosis , microbiology and biotechnology , cell growth , chemistry , glioblastoma , cancer research , reactive oxygen species , biology , biochemistry
Raddeanin A (RA), an active pharmacological ingredient from Anemone raddeana Regel, plays an important role in tumor suppression. In this study, we assessed the potentially therapeutic effect of RA on glioblastoma and its underlying mechanisms.