Open AccessNS3 Variability in Hepatitis C Virus Genotype 1A Isolates from Liver Tissue and Serum Samples of Treatment-Naïve Patients with Chronic Hepatitis C
Author(s) -
Deborah D’Aliberti,
Irene Cacciola,
Cristina Musolino,
G. Raffa,
Roberto Filomia,
Angela Alibrandi,
Salvatore Benfatto,
Concetta Beninati,
Carlo Saitta,
Domenico Giosa,
Orazio Romeo,
Giovanni Raimondo,
Teresa Pollicino
Publication year - 2018
Publication title -
intervirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.641
H-Index - 61
eISSN - 1423-0100
pISSN - 0300-5526
DOI - 10.1159/000489307
Subject(s) - viral quasispecies , ns3 , hepatitis c virus , virology , genotype , clade , hepacivirus , ribavirin , virus , hepatitis c , medicine , protease , biology , phylogenetic tree , gene , genetics , enzyme , biochemistry
Hepatitis C virus (HCV) NS3 resistance-associated substitutions (RASs) reduce HCV susceptibility to protease inhibitors. Little is known about NS3 RASs in viral isolates from the liver of chronic hepatitis C (CHC) patients infected with HCV genotype-1a (G1a).