NS3 Variability in Hepatitis C Virus Genotype 1A Isolates from Liver Tissue and Serum Samples of Treatment-Naïve Patients with Chronic Hepatitis C | Zendy

Deborah D’Aliberti | Zendy; Irene Cacciola | Zendy; Cristina Musolino | Zendy; G. Raffa | Zendy; Roberto Filomia | Zendy; Angela Alibrandi | Zendy; Salvatore Benfatto | Zendy; Concetta Beninati | Zendy; Carlo Saitta | Zendy; Domenico Giosa | Zendy; Orazio Romeo | Zendy; Giovanni Raimondo | Zendy; Teresa Pollicino | Zendy

Open Access

NS3 Variability in Hepatitis C Virus Genotype 1A Isolates from Liver Tissue and Serum Samples of Treatment-Naïve Patients with Chronic Hepatitis C

Author(s) -

Deborah D’Aliberti,

Irene Cacciola,

Cristina Musolino,

G. Raffa,

Roberto Filomia,

Angela Alibrandi,

Salvatore Benfatto,

Concetta Beninati,

Carlo Saitta,

Domenico Giosa,

Orazio Romeo,

Giovanni Raimondo,

Teresa Pollicino

Publication year - 2018

Publication title -

intervirology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.641

H-Index - 61

eISSN - 1423-0100

pISSN - 0300-5526

DOI - 10.1159/000489307

Subject(s) - viral quasispecies , ns3 , hepatitis c virus , virology , genotype , clade , hepacivirus , ribavirin , virus , hepatitis c , medicine , protease , biology , phylogenetic tree , gene , genetics , enzyme , biochemistry

Hepatitis C virus (HCV) NS3 resistance-associated substitutions (RASs) reduce HCV susceptibility to protease inhibitors. Little is known about NS3 RASs in viral isolates from the liver of chronic hepatitis C (CHC) patients infected with HCV genotype-1a (G1a).

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