Open AccessCharacterization of Siglec-8 Expression on Lavage Cells after Segmental Lung Allergen Challenge
Author(s) -
Mats W. Johansson,
Elizabeth A. Kelly,
Christopher L. Nguyen,
Nizar N. Jarjour,
Bruce S. Bochner
Publication year - 2018
Publication title -
international archives of allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.696
H-Index - 100
eISSN - 1423-0097
pISSN - 1018-2438
DOI - 10.1159/000488951
Subject(s) - siglec , immunology , bronchoalveolar lavage , eosinophil , flow cytometry , allergen , medicine , lung , allergy , asthma , immune system
Siglec-8 is present at a high level on human blood eosinophils and low level on blood basophils. Engagement of Siglec-8 on blood eosinophils causes its internalization and results in death. Siglec-8 is a potential therapeutic target in eosinophilic asthma.