Open AccessFatal Acute Hemolytic Transfusion Reaction due to Anti-Wra
Author(s) -
Tanaz Bahri,
Kim de Bruyn,
Rineke Leys,
Floor Weerkamp
Publication year - 2018
Publication title -
transfusion medicine and hemotherapy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.971
H-Index - 39
eISSN - 1660-3818
pISSN - 1660-3796
DOI - 10.1159/000488863
Subject(s) - medicine , antibody , hemolysis , red blood cell , blood transfusion , transfusion reaction , anemia , antigen , immunology , red cell , intensive care medicine
The Wr a blood group antigen is a low-frequency antigen. Antibody screening sets used in pretransfusion laboratory investigations usually do not contain a Wr(a+) cell. If subsequent cross-matching is performed without indirect antiglobulin test (IAT), Wr a antibodies reacting with donor red blood cells (RBCs) will be missed. For reasonable economic and time-saving arguments the risk of missing the detection of a potential clinically relevant antibody is worldwide accepted.