Open AccessSleep Disturbance and the Risk of Cognitive Decline or Clinical Conversion in the ADNI Cohort
Author(s) -
Adam P. Mecca,
Hannah R. Michalak,
Julia W. McDonald,
Emily C. Kemp,
Erika Pugh,
Melinda L. Becker,
Marcia C. Mecca,
Christopher H. van Dyck
Publication year - 2018
Publication title -
dementia and geriatric cognitive disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.026
H-Index - 110
eISSN - 1421-9824
pISSN - 1420-8008
DOI - 10.1159/000488671
Subject(s) - dementia , cognitive decline , cohort , sleep disorder , cognition , psychology , sleep (system call) , cohort study , alzheimer's disease , disturbance (geology) , audiology , disease , psychiatry , medicine , paleontology , computer science , biology , operating system
Background: We investigated the relationship between sleep disturbance and cognitive decline or clinical conversion in individuals with normal cognition (CN), as well as those with mild cognitive impairment (MCI) and dementia due to Alzheimer disease (AD-dementia). Methods: Secondary analysis of 1,629 adults between 48 and 91 years of age with up to 24 months of follow-up from the ADNI (Alzheimer’s Disease Neuroimaging Initiative), a longitudinal cohort study. Results: Sleep disturbance was not associated with decline in memory, executive function, or global cognition. The presence of sleep disturbance did not significantly increase the risk of diagnostic conversion in CN, early MCI, or late MCI participants. Conclusion: This study investigated the effect of sleep disturbance on cognitive decline using several outcomes and does not support the hypothesis that sleep disturbance predicts subsequent cognitive decline.