Open AccessThe Biological Effect and Clinical Application of Long Noncoding RNAs in Colorectal Cancer
Author(s) -
Zhenqiang Sun,
Zhibin Wang,
Chen Chen,
Quanbo Zhou,
Shenghong Yang,
Guixian Wang,
Junmin Song,
Zhen Li,
Zhiyong Zhang,
Jian Xu,
Xiantao Sun,
Yuan Chang,
Weitang Yuan
Publication year - 2018
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000488610
Subject(s) - long non coding rna , wnt signaling pathway , colorectal cancer , biology , biomarker , microrna , transcriptome , oncogene , mechanism (biology) , rna , metastasis , gene , bioinformatics , cancer , non coding rna , cancer research , computational biology , gene expression , genetics , cell cycle , philosophy , epistemology
Colorectal cancer (CRC) is one of the most common malignancies in the world. Easier recurrence and metastasis is the main cause of mortality in CRC patients, and the markers applied for diagnosis and treatment of CRC is still urgently needed to early diagnose and evaluate therapeutic effect. Long noncoding RNA (lncRNA) is a class of noncoding RNA that the length is more than 200 nucleotides. With the development of sequencing technique about transcriptome, increasing lncRNAs are focused on their function and mechanism related to the nosogenesis and pathology of CRC. Recent studies report that lncRNAs acted as crucial role in CRC and could be as biomarker for CRC diagnosis and treatment. In this review, we display the regulation of lncRNA by interacting with DNA, RNA and protein and highlight the double role of lncRNAs as oncogene or anti-tumor gene involved in Wnt signaling pathway, p53 signaling pathway or others to be an regulator in CRC development. Lastly, we discuss some new finding of lncRNAs, especially lncRNA in exosome, which could be as potential markers for diagnosis and treatment of CRC in future.