Open AccessFurther Evidence of an Association between <b><i>NCAN</i></b> rs1064395 and Bipolar Disorder
Author(s) -
Lu Wang,
Weiqing Liu,
Xingxing Li,
Xiao Xiao,
Lingyi Li,
Fang Liu,
Yuanfang He,
Yan Bai,
Hong Chang,
Dongsheng Zhou,
Ming Li
Publication year - 2018
Publication title -
complex psychiatry
Language(s) - English
Resource type - Journals
eISSN - 2673-3005
pISSN - 2673-298X
DOI - 10.1159/000488590
Subject(s) - association (psychology) , psychology , psychotherapist
Genome-wide association studies suggest that rs1064395 in the neurocan gene ( NCAN ) is a potential risk factor for bipolar disorder (BPD), and further replication analyses in larger independent samples are needed. We herein analyzed rs1064395 in a Han Chinese sample of 1,146 BPD cases and 2,031 controls, followed by a meta-analysis of BPD samples from worldwide populations including a total of 15,318 cases and 91,990 controls. The meta-analysis found that rs1064395 showed a genome-wide significant association with BPD ( p = 4.92 × 10 -9 , OR = 1.126 for the A allele), although it did not reach the significance level in the Han Chinese sample ( p = 0.415, OR = 1.070 for the A allele). We also examined the association between the single nucleotide polymorphisms and major depressive disorder (MDD) given the presumed genetic overlap between BPD and MDD, and rs1064395 was also associated with MDD ( p = 0.0068, OR = 1.067 for the A allele) in a meta-analysis of 14,543 cases and 14,856 controls. Our data provide further evidence for the involvement of NCAN in the genetic susceptibility to BPD and also implicate its broader role in major mood disorders.