Open AccessLarge-Volume Infusions into the Brain: A Comparative Study of Catheter Designs
Author(s) -
Martin Brady,
Raghu Raghavan,
Jaime F. Mata,
Mike Wilson,
Scott R. Wilson,
Rick M. Odland,
William C. Broaddus
Publication year - 2018
Publication title -
stereotactic and functional neurosurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.798
H-Index - 63
eISSN - 1423-0372
pISSN - 1011-6125
DOI - 10.1159/000488324
Subject(s) - catheter , medicine , volume (thermodynamics) , medical physics , anesthesia , surgery , quantum mechanics , physics
"Whole-brain" infusions have emerged as a potential need with the promise of disease-modifying therapies for neurodegenerative diseases. In addition, several current clinical trials in brain cancer utilize direct delivery of drugs that are required to fill large volumes. Such requirements may not be well served by conventional single port catheters with their "point source" of delivery. Our aim is to examine infusions into large volumes of heterogeneous tissue, aiming for uniformity of distribution.