Open AccessAngiotensin II Stimulates the NLRP3 Inflammasome to Induce Podocyte Injury and Mitochondrial Dysfunction
Author(s) -
Min Zhao,
Mei Bai,
Guofu Ding,
Yue Zhang,
Songming Huang,
Zhanjun Jia,
Aihua Zhang
Publication year - 2018
Publication title -
kidney diseases
Language(s) - English
Resource type - Journals
eISSN - 2296-9381
pISSN - 2296-9357
DOI - 10.1159/000488242
Subject(s) - inflammasome , podocyte , nephrin , podocin , angiotensin ii , pyrin domain , gene silencing , microbiology and biotechnology , medicine , chemistry , cancer research , endocrinology , kidney , biology , receptor , gene , biochemistry , proteinuria
We previously reported that the NLRP3 inflammasome played an important role in mediating the podocyte injury induced by aldosterone. However, more studies on the role of the NLRP3 inflammasome in the pathogenesis of podocytopathy are still required. The present study was undertaken to study the role of the NLRP3 inflammasome in angiotensin II (Ang II)-induced podocyte injury, as well as the potential mechanisms.