Open AccessSerum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students: The UP-AMIGOS Cohort Study
Author(s) -
Itzel VazquezVidal,
V. Saroja Voruganti,
Bridget A. Han,
Flávia Cristina Drumond Andrade,
Celia AradillasGarcía,
Manabu Nakamura,
Margarita Terán-García
Publication year - 2018
Publication title -
lifestyle genomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 30
eISSN - 2504-3188
pISSN - 2504-3161
DOI - 10.1159/000488085
Subject(s) - single nucleotide polymorphism , linkage disequilibrium , body mass index , biology , medicine , endocrinology , very low density lipoprotein , population , triglyceride , lipoprotein , genetics , genotype , cholesterol , gene , environmental health
Recent genome-wide association studies in the Mexican population have identified several genetic loci associated with blood lipid levels in adults. However, studies focusing on the fatty acid desaturase (FADS) gene cluster have been understudied in this population, even though it seems associated with lipid profiles in other ethnicities. The aim of this study was to test associations between single nucleotide polymorphisms (SNPs) in the FADS cluster (rs174546, rs1535, rs174548, rs174550, rs174450, and rs174618) and serum lipid profiles in young Mexicans.