Open AccessMembrane-Associated Kaposi Sarcoma-Associated Herpesvirus Glycoprotein B Promotes Cell Adhesion and Inhibits Migration of Cells via Upregulating IL-1β and TNF-α
Author(s) -
Hosni A. M. Hussein,
Usama M. Abdel-Raouf,
Shaw M. Akula
Publication year - 2017
Publication title -
intervirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.641
H-Index - 61
eISSN - 1423-0100
pISSN - 0300-5526
DOI - 10.1159/000487596
Subject(s) - cell adhesion , cell migration , transfection , paracrine signalling , microbiology and biotechnology , autocrine signalling , tumor necrosis factor alpha , adhesion , biology , cell , focal adhesion , chemistry , cell culture , immunology , signal transduction , biochemistry , receptor , organic chemistry , genetics
Kaposi sarcoma-associated herpesvirus (KSHV) glycoprotein B (gB) is expressed on the viral envelope as well as on the cytoplasmic membrane of infected cells. In the current study, we aimed to decipher the impact of membrane-associated gB on adhesion and migration of cells via modulating the expression of cytokines.