Open AccessA Novel Method to Detect Early Colorectal Cancer Based on Chromosome Copy Number Variation in Plasma
Author(s) -
Junfeng Xu,
Qian Kang,
Xing-yong Ma,
Yuanming Pan,
Lang Yang,
Peng Jin,
Xin Wang,
Chenguang Li,
Xiaochen Chen,
Chao Wu,
Shao-zhuo Jiao,
Jian-qiu Sheng
Publication year - 2018
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000487571
Subject(s) - colorectal cancer , copy number variation , colonoscopy , medicine , oncology , cancer , biology , gastroenterology , genome , genetics , gene
Colonoscopy screening has been accepted broadly to evaluate the risk and incidence of colorectal cancer (CRC) during health examination in outpatients. However, the intrusiveness, complexity and discomfort of colonoscopy may limit its application and the compliance of patients. Thus, more reliable and convenient diagnostic methods are necessary for CRC screening. Genome instability, especially copy-number variation (CNV), is a hallmark of cancer and has been proved to have potential in clinical application.