Open AccessThe Genetic and Environmental Factors of Primary Membranous Nephropathy: An Overview from China
Author(s) -
Xiaodan Zhang,
Zhao Cui,
MingHui Zhao
Publication year - 2018
Publication title -
kidney diseases
Language(s) - English
Resource type - Journals
eISSN - 2296-9381
pISSN - 2296-9357
DOI - 10.1159/000487136
Subject(s) - membranous nephropathy , allele , odds ratio , immunology , human leukocyte antigen , genotype , genetics , medicine , gene , biology , antigen , glomerulonephritis , kidney
Primary membranous nephropathy (pMN) is the most common cause of nephrotic syndrome in adults. The discovery of the 2 autoantigens, M-type phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A), has defined pMN as an autoimmune disease. A remarkable increase in the frequency of pMN in primary glomerular disease was witnessed in China. The genetic and environmental contributors to disease susceptibility have been investigated in these patients.