Open AccessMotor Recovery after Transplantation of Bone Marrow Mesenchymal Stem Cells in Rat Models of Spinal Cord Injury
Author(s) -
Durai Murugan Muniswami,
Praghalathan Kanthakumar,
Indirani Kanakasabapathy,
George Tharion
Publication year - 2018
Publication title -
annals of neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.545
H-Index - 19
eISSN - 0976-3260
pISSN - 0972-7531
DOI - 10.1159/000487069
Subject(s) - mesenchymal stem cell , medicine , bone marrow , transplantation , neun , pathology , spinal cord injury , cd90 , stem cell , cd34 , stem cell transplantation for articular cartilage repair , spinal cord , adult stem cell , biology , embryonic stem cell , immunohistochemistry , microbiology and biotechnology , psychiatry , biochemistry , gene
Neuronal tissue has a limited potential to self-renew or get repaired after damage. Cell therapies using stem cells are promising approaches for the treatment of central nervous system (CNS) injuries. However, the clinical use of embryonic stem cells is limited by ethical concerns and other scientific consequences. Bone marrow mesenchymal stromal cells (BM-MSC) could represent an alternative source of stem cells for replacement therapy. Indeed, many studies have demonstrated that MSCs can give rise to neuronal cells as well as many tissue-specific cell phenotypes.