Open AccessElevated HPV16 E1 Expression Is Associated with Cervical Cancer Progression
Author(s) -
Fern Baedyananda,
Arkom Chaiwongkot,
Parvapan Bhattarakosol
Publication year - 2017
Publication title -
intervirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.641
H-Index - 61
eISSN - 1423-0100
pISSN - 0300-5526
DOI - 10.1159/000487048
Subject(s) - promoter , methylation , biology , cancer , dna methylation , microbiology and biotechnology , cervical cancer , real time polymerase chain reaction , cancer research , gene , gene expression , genetics
The primary replication protein, HPV E1, has been shown to play a role in mitigating host defence and disrupting normal cell cycle processes, leading to the development of cancer. This study investigated the expression profile of HPV16 E1 in various stages of cervical cancer development and the factors that control E1 expression.