Open AccessSkeletal Extracellular Matrix Supports Cardiac Differentiation of Embryonic Stem Cells: a Potential Scaffold for Engineered Cardiac Tissue
Author(s) -
Xin Hong,
Yuan Yin,
Xiaoxi Sun,
Minfeng Zhou,
Guangyu Guo,
Quan Zhang,
Juergen Hescheler,
Jun Xi
Publication year - 2018
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000486813
Subject(s) - decellularization , embryonic stem cell , extracellular matrix , microbiology and biotechnology , tissue engineering , chemistry , stem cell , cardiac muscle , biomedical engineering , biology , anatomy , medicine , biochemistry , gene
Decellularized cardiac extracellular matrix (cECM) has been widely considered as an attractive scaffold for engineered cardiac tissue (ECT), however, its application is limited by immunogenicity and shortage of organ donation. Skeletal ECM (sECM) is readily available and shows similarities with cECM. Here we hypothesized that sECM might be an alternative scaffold for ECT strategies.