Open AccessGinsenoside Rb1 Protects the Brain from Damage Induced by Epileptic Seizure via Nrf2/ARE Signaling
Author(s) -
YunBo Shi,
Miao Wang,
Junfang Teng,
Lingli Zhang
Publication year - 2018
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000486768
Subject(s) - morris water navigation task , pentylenetetrazol , propidium iodide , neuroprotection , pharmacology , brain damage , chemistry , astrocyte , hippocampus , medicine , apoptosis , epilepsy , endocrinology , programmed cell death , biochemistry , anticonvulsant , central nervous system , psychiatry
Ginsenoside Rb1 (Rb1) has been reported to have varieties of neuroprotective effects. This study aimed to evaluate the effects of Rb1 on pentylenetetrazol (PTZ)-induced rat brain injury and Mg2+ free-induced neuron injury and analyzed the detailed molecular mechanisms in vivo and in vitro.