A Novel Animal Model of Parkinson’s Disease Using Optogenetics: Representation of Various Disease Stages by Modulating the Illumination Parameter | Zendy

Eun Jung Lee | Zendy; Hyung Ho Yoon | Zendy; Eun Suk Park | Zendy; Joongkee Min | Zendy; Sang Ryong Jeon | Zendy

Open Access

A Novel Animal Model of Parkinson’s Disease Using Optogenetics: Representation of Various Disease Stages by Modulating the Illumination Parameter

Author(s) -

Eun Jung Lee,

Hyung Ho Yoon,

Eun Suk Park,

Joongkee Min,

Sang Ryong Jeon

Publication year - 2018

Publication title -

stereotactic and functional neurosurgery

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.798

H-Index - 63

eISSN - 1423-0372

pISSN - 1011-6125

DOI - 10.1159/000486644

Subject(s) - optogenetics , substantia nigra , pars compacta , parkinson's disease , deep brain stimulation , neuroscience , stimulation , forelimb , animal model , halorhodopsin , midbrain , medicine , biomedical engineering , chemistry , disease , biology , pathology , biochemistry , central nervous system , bacteriorhodopsin , membrane

The classic animal model of Parkinson's disease (PD) using neurotoxin can only simulate fixed stages of the disease by causing irreversible damage to the nigrostriatal system.

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