Open AccessA Novel Animal Model of Parkinson’s Disease Using Optogenetics: Representation of Various Disease Stages by Modulating the Illumination Parameter
Author(s) -
Eun Jung Lee,
Hyun Soo Yoon,
Eun Suk Park,
Joongkee Min,
Sang Ryong Jeon
Publication year - 2018
Publication title -
stereotactic and functional neurosurgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.798
H-Index - 63
eISSN - 1423-0372
pISSN - 1011-6125
DOI - 10.1159/000486644
Subject(s) - optogenetics , substantia nigra , pars compacta , parkinson's disease , deep brain stimulation , neuroscience , stimulation , forelimb , animal model , halorhodopsin , midbrain , medicine , biomedical engineering , chemistry , disease , biology , pathology , biochemistry , central nervous system , bacteriorhodopsin , membrane
The classic animal model of Parkinson's disease (PD) using neurotoxin can only simulate fixed stages of the disease by causing irreversible damage to the nigrostriatal system.