Open AccessVitamin E Analogue Protects Red Blood Cells against Storage-Induced Oxidative Damage
Author(s) -
Adam Antosik,
Kamila Czubak,
Natalia Cichoń,
Paweł Nowak,
Halina Małgorzata Żbikowska
Publication year - 2018
Publication title -
transfusion medicine and hemotherapy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.971
H-Index - 39
eISSN - 1660-3818
pISSN - 1660-3796
DOI - 10.1159/000486605
Subject(s) - trolox , tbars , lipid peroxidation , chemistry , hemolysis , mannitol , biochemistry , glutathione , vitamin e , red blood cell , antioxidant , biology , immunology , enzyme , dpph
To investigate i) the effects of Trolox® or mannitol, which represent two different classes of antioxidants, on oxidative changes generated in manually isolated red blood cells (RBCs) from citrate-phosphate-dextrose (CPD) preserved whole blood, followed by up to 20 days refrigerated storage, and ii) whether Trolox supplemented to the blood bank-manufactured saline-adenine-glucose-mannitol (SAGM) preserved RBC units would offer better storage conditions compared with SAGM alone.