Vitamin E Analogue Protects Red Blood Cells against Storage-Induced Oxidative Damage | Zendy

Adam Antosik | Zendy; Kamila Czubak-Prowizor | Zendy; Natalia Cichoń | Zendy; Paweł Nowak | Zendy; Halina Małgorzata Żbikowska | Zendy

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Vitamin E Analogue Protects Red Blood Cells against Storage-Induced Oxidative Damage

Author(s) -

Adam Antosik,

Kamila Czubak-Prowizor,

Natalia Cichoń,

Paweł Nowak,

Halina Małgorzata Żbikowska

Publication year - 2018

Publication title -

transfusion medicine and hemotherapy

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 39

eISSN - 1660-3818

pISSN - 1660-3796

DOI - 10.1159/000486605

Subject(s) - trolox , tbars , lipid peroxidation , chemistry , hemolysis , mannitol , biochemistry , glutathione , vitamin e , red blood cell , antioxidant , biology , immunology , enzyme , dpph

To investigate i) the effects of Trolox® or mannitol, which represent two different classes of antioxidants, on oxidative changes generated in manually isolated red blood cells (RBCs) from citrate-phosphate-dextrose (CPD) preserved whole blood, followed by up to 20 days refrigerated storage, and ii) whether Trolox supplemented to the blood bank-manufactured saline-adenine-glucose-mannitol (SAGM) preserved RBC units would offer better storage conditions compared with SAGM alone.

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