Open AccessMicroRNA-9a-5p Alleviates Ischemia Injury After Focal Cerebral Ischemia of the Rat by Targeting ATG5-Mediated Autophagy
Author(s) -
Ning Wang,
Yang Lei,
Huixue Zhang,
Xiaoyu Lu,
Jianjian Wang,
Yuze Cao,
Lixia Chen,
Xiaokun Wang,
Cong Liu,
Jie Li,
Na Wang,
Zhaojun Liu,
Lihua Wang
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000486224
Subject(s) - autophagy , atg5 , ischemia , microrna , luciferase , blot , medicine , messenger rna , stroke (engine) , transfection , microbiology and biotechnology , apoptosis , cell culture , chemistry , biology , biochemistry , gene , mechanical engineering , genetics , engineering
Previous studies have suggested that autophagy is activated in distinct cerebrovascular diseases, including stroke. However, the underlying regulatory mechanism of autophagy under stroke remained elusive. Accumulating evidence indicates that dysfunctions of microRNAs (miRNAs) are involved in the pathological process of stroke. Therefore, this study was taken to identify the effect of microRNA-9a-5p (miR-9a-5p) on autophagy in rats following stroke.