Open AccessArteriovenous Sphingosine-1-Phosphate Differences Across Selected Organs of the Rat
Author(s) -
Monika Książek,
Urszula Baranowska,
Adrian Chabowski,
Marcin Baranowski
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000486223
Subject(s) - sphingosine , medicine , albumin , endocrinology , blood plasma , ventricle , aorta , sphingosine 1 phosphate , chemistry , abdominal aorta , sphingolipid , biochemistry , receptor
Sphingosine-1-phosphate (S1P) is a bioactive lysosphingolipid that is found in high concentration in plasma. The majority of plasma S1P is transported bound to HDL and albumin. Although the major sources of circulating S1P have been identified, it remains obscure what is the contribution of different organs/tissues to S1P homeostasis in plasma. Answering this question was the major aim of the present study.