Oocyte Cytoplasmic Gas6 and Heparan Sulfate (HS) are Required to Establish the Open Chromatin State in Nuclei During Remodeling and Reprogramming | Zendy

KyeoungHwa Kim | Zendy; EunYoung Kim | Zendy; SuYeon Lee | Zendy; Jung-Jae Ko | Zendy; KyungAh Lee | Zendy

Open Access

Oocyte Cytoplasmic Gas6 and Heparan Sulfate (HS) are Required to Establish the Open Chromatin State in Nuclei During Remodeling and Reprogramming

Author(s) -

KyeoungHwa Kim,

EunYoung Kim,

SuYeon Lee,

Jung-Jae Ko,

KyungAh Lee

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000486221

Subject(s) - micrococcal nuclease , microbiology and biotechnology , chromatin , biology , oocyte , somatic cell , chemistry , biochemistry , gene , embryo , nucleosome

Previously, we found that silencing of growth arrest-specific gene 6 (Gas6) in oocytes impaired cytoplasmic maturation, resulting in failure of sperm chromatin decondensation (SCD) and pronuclear (PN) formation after fertilization. Thus, we conducted this study to determine the effect of Gas6 RNAi on downstream genes and to elucidate the working mechanism of Gas6 on oocyte cytoplasmic maturation and SCD.

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