Open AccessDecreased IFIT2 Expression Promotes Gastric Cancer Progression and Predicts Poor Prognosis of the Patients
Author(s) -
Lüjun Chen,
Wensi Zhai,
Xiao Zheng,
Quanqin Xie,
Qi Zhou,
Min Tao,
Yueyong Zhu,
Changping Wu,
Jingting Jiang
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000486219
Subject(s) - cancer , gene knockdown , cancer cell , cancer research , biology , medicine , pathology , cell culture , genetics
The status of interferon (IFN) signaling pathway has been shown to be closely associated with the response of immune checkpoint blockade therapy against advanced human cancers. IFN-induced protein with tetratricopeptide repeats 2 (IFIT2), also known as IFN-stimulated gene 54 (ISG54), is one of the most highly responsive ISGs, which can inhibit the proliferation and migration of cancer cells, and regulate viral replication, resulting in anti-cancer and anti-viral effects. In the present study, we aimed to investigate the role of IFIT2 in human gastric cancer.