Open AccessAstragaloside IV Prevents Cardiac Remodeling in the Apolipoprotein E-Deficient Mice by Regulating Cardiac Homeostasis and Oxidative Stress
Author(s) -
Xiong-Zhi Li,
Yanzi Ding,
Hengfang Wu,
Zhiping Bian,
Jing Xu,
Zhuoshi Li,
Xiangjian Chen,
Di Yang
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000486166
Subject(s) - medicine , endocrinology , oxidative stress , apolipoprotein e , ejection fraction , cardiac function curve , nox4 , myocyte , nadph oxidase , ventricular remodeling , biology , chemistry , heart failure , disease
Hypercholesterolemia is a risk factor for the development of cardiac hypertrophy. Astragaloside IV (AST-IV) possesses cardiovascular protective properties. We hypothesize that AST-IV prevents cardiac remodeling with hypercholesterolemia via modulating tissue homeostasis and alleviating oxidative stress.