Astragaloside IV Prevents Cardiac Remodeling in the Apolipoprotein E-Deficient Mice by Regulating Cardiac Homeostasis and Oxidative Stress | Zendy

Xiong-Zhi Li | Zendy; Yanzi Ding | Zendy; Hengfang Wu | Zendy; Zhiping Bian | Zendy; Jin-Dan Xu | Zendy; Chunrong Gu | Zendy; Xiangjian Chen | Zendy; Di Yang | Zendy

Open Access

Astragaloside IV Prevents Cardiac Remodeling in the Apolipoprotein E-Deficient Mice by Regulating Cardiac Homeostasis and Oxidative Stress

Author(s) -

Xiong-Zhi Li,

Yanzi Ding,

Hengfang Wu,

Zhiping Bian,

Jin-Dan Xu,

Chunrong Gu,

Xiangjian Chen,

Di Yang

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000486166

Subject(s) - medicine , endocrinology , oxidative stress , apolipoprotein e , ejection fraction , cardiac function curve , nox4 , myocyte , nadph oxidase , ventricular remodeling , biology , chemistry , heart failure , disease

Hypercholesterolemia is a risk factor for the development of cardiac hypertrophy. Astragaloside IV (AST-IV) possesses cardiovascular protective properties. We hypothesize that AST-IV prevents cardiac remodeling with hypercholesterolemia via modulating tissue homeostasis and alleviating oxidative stress.

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