Open AccessMelatonin Relieves Busulfan-Induced Spermatogonial Stem Cell Apoptosis of Mouse Testis by Inhibiting Endoplasmic Reticulum Stress
Author(s) -
Yanhua Cui,
Liang Ren,
Bo Li,
Jia You Fang,
Yuanxin Zhai,
Xin He,
Jianxiao Wang,
YiLiang Miao,
Jinlian Hua,
Sha Peng
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000486165
Subject(s) - busulfan , endoplasmic reticulum , apoptosis , melatonin , biology , chop , andrology , endocrinology , medicine , microbiology and biotechnology , pharmacology , cancer research , stem cell , biochemistry , hematopoietic stem cell transplantation
Busulfan is commonly used for cancer chemotherapy. Although it has the advantage of increasing the survival rate of patients, it can cause male infertility via damaging the testes and reducing sperm counts. Therefore, the underlying mechanism should be explored, and new agents should be developed to protect the male reproductive system from busulfan-induced damage. Endoplasmic reticulum stress (ERS) is considered a key contributor to numerous pathologies. Despite several studies linking ERS to toxicants, studies have yet to determine whether ERS is a contributing factor to busulfan-induced testicular damage. Melatonin is a well-known broad-spectrum antioxidant, anti-inflammatory and antitumour agent, but the effects of melatonin on busulfan-induced ERS in mouse testes damage are less documented.