Open AccessIntegrated Treatment during the Intravitreal Melphalan Era: Concurrent Intravitreal Melphalan and Systemic Chemoreduction
Author(s) -
Jesse L. Berry,
Sona Shah,
Fiona Kim,
Rima Jubran,
Jonathan W. Kim
Publication year - 2018
Publication title -
ocular oncology and pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.444
H-Index - 10
eISSN - 2296-4681
pISSN - 2296-4657
DOI - 10.1159/000486098
Subject(s) - medicine , melphalan , surgery , etoposide , carboplatin , salvage therapy , chemotherapy , anesthesia , cisplatin
Intravitreal injection of melphalan (IVM) is safe and effective for the treatment of seeding in retinoblastoma. Current protocols require weekly injections during examination under anesthesia (EUA). To avoid additional anesthesia exposure for these children, IVM was initiated at the EUA concurrent with the 4th cycle of systemic chemoreduction in a series of 6 patients with persistent seeding.