Open AccessCharacteristic MicroRNA Expression Induced by δ-Opioid Receptor Activation in the Rat Liver Under Prolonged Hypoxia
Author(s) -
Feng Zhi,
Nan Shao,
Ling Xue,
Yuan Xu,
Xiaoming Kang,
Yilin Yang,
Ying Xia
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000486067
Subject(s) - microrna , hypoxia (environmental) , downregulation and upregulation , biology , taqman , medicine , real time polymerase chain reaction , endocrinology , pharmacology , cancer research , chemistry , gene , biochemistry , oxygen , organic chemistry
Hypoxic/ischemic injury to the liver is a frequently encountered clinical problem with limited therapeutic options. Since microRNAs (miRNAs) are involved in hypoxic/ ischemic events, and δ-opioid receptor (DOR) is protective against hypoxic/ischemic injury, we asked if pharmacological activation of DOR can alter hypoxic events by regulating miRNA expression in the liver. As the first step, the present work aimed at testing the effect of DOR activation on hepatic miRNA expression in hypoxia.