NLRP3 Gene Deletion Attenuates Angiotensin II-Induced Phenotypic Transformation of Vascular Smooth Muscle Cells and Vascular Remodeling | Zendy

Xingsheng Ren | Zendy; Ying Tong | Zendy; Li Ling | Zendy; Dan Chen | Zendy; HaiJian Sun | Zendy; Hong Zhou | Zendy; Xiaohong Qi | Zendy; Qi Chen | Zendy; Yuehua Li | Zendy; YuMing Kang | Zendy; GuoQing Zhu | Zendy

Open Access

NLRP3 Gene Deletion Attenuates Angiotensin II-Induced Phenotypic Transformation of Vascular Smooth Muscle Cells and Vascular Remodeling

Author(s) -

Xingsheng Ren,

Ying Tong,

Li Ling,

Dan Chen,

HaiJian Sun,

Hong Zhou,

Xiaohong Qi,

Qi Chen,

Yuehua Li,

YuMing Kang,

GuoQing Zhu

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000486061

Subject(s) - vascular smooth muscle , inflammasome , angiotensin ii , downregulation and upregulation , phenotype , vascular remodelling in the embryo , inflammation , medicine , microbiology and biotechnology , endocrinology , chemistry , biology , receptor , gene , smooth muscle , biochemistry

Angiotensin (Ang) II plays vital roles in vascular inflammation and remodeling in hypertension. Phenotypic transformation of vascular smooth muscle cells (VSMCs) is a major initiating factor for vascular remodeling. The present study was designed to determine the roles of NLRP3 inflammasome activation in Ang II-induced VSMC phenotypic transformation and vascular remodeling in hypertension.

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