Open AccessNLRP3 Gene Deletion Attenuates Angiotensin II-Induced Phenotypic Transformation of Vascular Smooth Muscle Cells and Vascular Remodeling
Author(s) -
Xingsheng Ren,
Ying Tong,
Ling Li,
Dan Chen,
Hai-Jian Sun,
Hong Zhou,
Xinming Qi,
Qi Chen,
Yuehua Li,
Yu-Ming Kang,
GuoQing Zhu
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000486061
Subject(s) - vascular smooth muscle , inflammasome , angiotensin ii , downregulation and upregulation , phenotype , vascular remodelling in the embryo , inflammation , medicine , microbiology and biotechnology , endocrinology , chemistry , biology , receptor , gene , smooth muscle , biochemistry
Angiotensin (Ang) II plays vital roles in vascular inflammation and remodeling in hypertension. Phenotypic transformation of vascular smooth muscle cells (VSMCs) is a major initiating factor for vascular remodeling. The present study was designed to determine the roles of NLRP3 inflammasome activation in Ang II-induced VSMC phenotypic transformation and vascular remodeling in hypertension.