Open AccessThe Rise, Fall, and Resurrection of 11-Oxygenated Androgens in Human Physiology and Disease
Author(s) -
Adina F. Turcu,
Aya T Nanba,
Richard J. Auchus
Publication year - 2018
Publication title -
hormone research in paediatrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.816
H-Index - 89
eISSN - 1663-2826
pISSN - 1663-2818
DOI - 10.1159/000486036
Subject(s) - androgen , disease , endocrinology , androgen excess , human disease , testosterone (patch) , medicine , physiology , biology , hormone , insulin resistance , polycystic ovary , insulin
The 11-oxyandrogens, particularly 11-ketotestosterone, have been recognized as a biologically important gonadal androgen in teleost (bony) fishes for decades, and their presence in human beings has been known but poorly understood. Today, we recognize that 11-oxyandrogens derive from the human adrenal glands and are major bioactive androgens, particularly in women and children. This article will review their biosynthesis and metabolism, abundance in normal and pathologic states, and potential as biomarkers of adrenal developmental changes and disease. Specifically, 11-oxyandrogens are the dominant active androgens in many patients with 21-hydroxylase deficiency.